Version 5.4
Homo sapiens Protein: POLE4
Summary
InnateDB Protein IDBP-475079.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLE4
Protein Name polymerase (DNA-directed), epsilon 4 (p12 subunit)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000420176
InnateDB Gene IDBG-58113 (POLE4)
Protein Structure
UniProt Annotation
Function May play a role in allowing polymerase epsilon to carry out its replication and/or repair function.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006261 DNA-dependent DNA replication
GO:0043966 histone H3 acetylation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex
GO:0008622 epsilon DNA polymerase complex
Protein Structure and Domains
PDB ID
InterPro IPR003958 Transcription factor CBF/NF-Y/archaeal histone
IPR007125 Histone core
IPR009072 Histone-fold
PFAM PF00808
PF00125
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NR33
PhosphoSite PhosphoSite-Q9NR33
TrEMBL
UniProt Splice Variant
Entrez Gene 56655
UniGene
RefSeq NP_063949
HUGO HGNC:18755
OMIM 607269
CCDS CCDS1957
HPRD 16238
IMGT
EMBL AC007400 AF261688 BC031331
GenPept AAF90132 AAH31331 AAY15030

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca