InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CASP3

Summary

InnateDB Protein

IDBP-475126.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CASP3

Protein Name

caspase 3, apoptosis-related cysteine peptidase

Synonyms

CPP32; CPP32B; SCA-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000428929

InnateDB Gene

IDBG-46394 (CASP3)

Protein Structure

UniProt Annotation

Function

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp--Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. {ECO:0000269PubMed:21357690, ECO:0000269PubMed:7596430}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 199 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	199 [view]
Protein-Protein	197 [view]
Protein-DNA	0
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004190	aspartic-type endopeptidase activity
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process
GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis

Biological Process

GO:0006309	apoptotic DNA fragmentation
GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0022617	extracellular matrix disassembly
GO:0030182	neuron differentiation
GO:0030198	extracellular matrix organization
GO:0030216	keratinocyte differentiation
GO:0030218	erythrocyte differentiation
GO:0030220	platelet formation
GO:0034612	response to tumor necrosis factor
GO:0035329	hippo signaling
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0097190	apoptotic signaling pathway
GO:0097193	intrinsic apoptotic signaling pathway
GO:0097194	execution phase of apoptosis

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001309 Peptidase C14, ICE, catalytic subunit p20
IPR002138 Peptidase C14, caspase non-catalytic subunit p10
IPR011600 Peptidase C14, caspase domain
IPR015917 Peptidase C14A, caspase precursor p45, core

PFAM

PF00656

PRINTS

PR00376

PIRSF

SMART

SM00115

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt