InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GMPS

Summary

InnateDB Protein

IDBP-475140.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GMPS

Protein Name

guanine monphosphate synthetase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000419851

InnateDB Gene

IDBG-62407 (GMPS)

Protein Structure

UniProt Annotation

Function

Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division.

Subcellular Localization

Cytoplasm.

Disease Associations

Note=A chromosomal aberration involving GMPS is found in acute myeloid leukemias. Translocation t(3,11)(q25,q23) with KMT2A/MLL1.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	34 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003921	GMP synthase activity
GO:0003922	GMP synthase (glutamine-hydrolyzing) activity
GO:0004066	asparagine synthase (glutamine-hydrolyzing) activity
GO:0005524	ATP binding
GO:0016462	pyrophosphatase activity
GO:0016740	transferase activity
GO:0016787	hydrolase activity
GO:0019899	enzyme binding

Biological Process

GO:0006144	purine nucleobase metabolic process
GO:0006164	purine nucleotide biosynthetic process
GO:0006177	GMP biosynthetic process
GO:0006529	asparagine biosynthetic process
GO:0006541	glutamine metabolic process
GO:0008033	tRNA processing
GO:0009113	purine nucleobase biosynthetic process
GO:0009168	purine ribonucleoside monophosphate biosynthetic process
GO:0042493	response to drug
GO:0044281	small molecule metabolic process
GO:0055086	nucleobase-containing small molecule metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR001674 GMP synthase, C-terminal
IPR001962 Asparagine synthase
IPR004506 tRNA-specific 2-thiouridylase
IPR004739 GMP synthase, N-terminal
IPR011697 Peptidase C26
IPR017926 Glutamine amidotransferase
IPR018317 Queuosine biosynthesis protein QueC
IPR022310 NAD/GMP synthase
IPR029062 Class I glutamine amidotransferase-like

PFAM