InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NPY5R

Summary

InnateDB Protein

IDBP-475249.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPY5R

Protein Name

neuropeptide Y receptor Y5

Synonyms

NPY5-R; NPYR5; NPYY5-R;

Species

Homo sapiens

Ensembl Protein

ENSP00000423917

InnateDB Gene

IDBG-43252 (NPY5R)

Protein Structure

UniProt Annotation

Function

Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Brain; hypothalamus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001601	peptide YY receptor activity
GO:0001602	pancreatic polypeptide receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004983	neuropeptide Y receptor activity

Biological Process

GO:0002675	positive regulation of acute inflammatory response
GO:0003151	outflow tract morphogenesis
GO:0003214	cardiac left ventricle morphogenesis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007268	synaptic transmission
GO:0014050	negative regulation of glutamate secretion
GO:0032229	negative regulation of synaptic transmission, GABAergic
GO:0042755	eating behavior
GO:0043066	negative regulation of apoptotic process
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0060112	generation of ovulation cycle rhythm

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000393 Neuropeptide Y5 receptor
IPR000611 Neuropeptide Y receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR01016
PR01012

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q15761