InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DZIP3

Summary

InnateDB Protein

IDBP-475312.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DZIP3

Protein Name

DAZ interacting protein 3, zinc finger

Synonyms

hRUL138; PPP1R66; UURF2;

Species

Homo sapiens

Ensembl Protein

ENSP00000418871

InnateDB Gene

IDBG-49039 (DZIP3)

Protein Structure

UniProt Annotation

Function

E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA. {ECO:0000269PubMed:12538761}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12538761}.

Disease Associations

Tissue Specificity

Widely expressed at low level. Highly expressed in skeletal muscle, kidney and heart. Expressed at low level in placenta, lung, brain, liver and pancreas. {ECO:0000269PubMed:12538761}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	42 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0019902	phosphatase binding
GO:0031593	polyubiquitin binding
GO:0044822	poly(A) RNA binding