Version 5.4
Homo sapiens Protein: NACA2
Summary
InnateDB Protein IDBP-475461.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NACA2
Protein Name nascent polypeptide-associated complex alpha subunit 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000427802
InnateDB Gene IDBG-408432 (NACA2)
Protein Structure
UniProt Annotation
Function Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed specifically in testis and skeletal muscle. {ECO:0000269PubMed:16201836}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0017025 TBP-class protein binding
Biological Process
GO:0015031 protein transport
GO:0051451 myoblast migration
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR002715 Nascent polypeptide-associated complex NAC domain
IPR009060 UBA-like
IPR016641 Nascent polypeptide-associated complex subunit alpha
PFAM PF01849
PRINTS
PIRSF PIRSF015901
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H009
PhosphoSite PhosphoSite-Q9H009
TrEMBL
UniProt Splice Variant
Entrez Gene 342538
UniGene Hs.591178
RefSeq NP_954984
HUGO HGNC:23290
OMIM 609274
CCDS CCDS11630
HPRD 16487
IMGT
EMBL AJ278883 BC062710 DQ120612
GenPept AAH62710 ABB92399 CAC06614

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca