InnateDB Protein
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IDBP-475566.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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S100A14
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Protein Name
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S100 calcium binding protein A14
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000420296
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InnateDB Gene
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IDBG-102727 (S100A14)
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Protein Structure
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Function |
Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium. {ECO:0000269PubMed:21559403, ECO:0000269PubMed:22032898, ECO:0000269PubMed:22451655}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:11944983}.
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Disease Associations |
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Tissue Specificity |
Expressed at highest levels in colon and at moderate levels in thymus, kidney, liver, small intestine, and lung. Low expression in heart and no expression is seen in brain, skeletal muscle, spleen, placenta and peripheral blood leukocytes. {ECO:0000269PubMed:11944983}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR013787
S100/CaBP-9k-type, calcium binding, subdomain
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PFAM |
PF01023
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9HCY8
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PhosphoSite |
PhosphoSite-Q9HCY8
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
57402
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UniGene |
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RefSeq |
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HUGO |
HGNC:18901
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OMIM |
607986
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CCDS |
CCDS1046
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HPRD |
10467
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IMGT |
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EMBL |
AF426828
AY007220
BC005019
BX470102
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GenPept |
AAG01893
AAH05019
AAM19206
CAI14759
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