InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TXLNG

Summary

InnateDB Protein

IDBP-47577.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TXLNG

Protein Name

taxilin gamma

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000369465

InnateDB Gene

IDBG-47575 (TXLNG)

Protein Structure

UniProt Annotation

Function

May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression. {ECO:0000269PubMed:15911876, ECO:0000269PubMed:18068885}.

Subcellular Localization

Nucleus membrane {ECO:0000269PubMed:15911876}. Cytoplasm, cytosol {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Expressed at high level in heart and skeletal muscle. Expressed in brain, placenta, lung, liver, kidney and pancreas. {ECO:0000269PubMed:15184072}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019905	syntaxin binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007049	cell cycle
GO:0010564	regulation of cell cycle process
GO:0030500	regulation of bone mineralization
GO:0051726	regulation of cell cycle