Version 5.4
Homo sapiens Protein: MURC
Summary
InnateDB Protein IDBP-475794.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MURC
Protein Name muscle-related coiled-coil protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000418668
InnateDB Gene IDBG-78896 (MURC)
Protein Structure
UniProt Annotation
Function Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway. {ECO:0000269PubMed:18332105}.
Subcellular Localization Cytoplasm, myofibril, sarcomere {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=In cardiomyocytes, accumulates in the Z-line of the sarcomere. In vascular smooth muscle cells, detected diffusely throughout the cytoplasm (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006351 transcription, DNA-templated
GO:0007517 muscle organ development
GO:0030154 cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005737 cytoplasm
GO:0030018 Z disc
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5BKX8
PhosphoSite PhosphoSite-Q5BKX8
TrEMBL
UniProt Splice Variant
Entrez Gene 347273
UniGene
RefSeq NP_001018126
HUGO HGNC:33742
OMIM
CCDS CCDS35083
HPRD 18599
IMGT
EMBL AK300099 AL354917 BC090888 EU487253
GenPept AAH90888 ACA62935 BAG61900

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca