InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADAM9

Summary

InnateDB Protein

IDBP-475819.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADAM9

Protein Name

ADAM metallopeptidase domain 9

Synonyms

CORD9; MCMP; MDC9; Mltng;

Species

Homo sapiens

Ensembl Protein

ENSP00000419446

InnateDB Gene

IDBG-18369 (ADAM9)

Protein Structure

UniProt Annotation

Function

Probable zinc protease. May mediate cell-cell or cell- matrix interactions. Isoform 2 displays alpha-secretase activity for APP. {ECO:0000269PubMed:12054541}.

Subcellular Localization

Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted.

Disease Associations

Cone-rod dystrophy 9 (CORD9) [MIM:612775]: An inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa. {ECO:0000269PubMed:19409519}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart. {ECO:0000269PubMed:12054541, ECO:0000269PubMed:7584026, ECO:0000269PubMed:8647900, ECO:0000269PubMed:9016778}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005080	protein kinase C binding
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding
GO:0017124	SH3 domain binding
GO:0043236	laminin binding

Biological Process

GO:0000186	activation of MAPKK activity
GO:0006508	proteolysis
GO:0006509	membrane protein ectodomain proteolysis
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007229	integrin-mediated signaling pathway
GO:0010042	response to manganese ion
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030216	keratinocyte differentiation
GO:0030574	collagen catabolic process
GO:0033627	cell adhesion mediated by integrin
GO:0033630	positive regulation of cell adhesion mediated by integrin
GO:0033631	cell-cell adhesion mediated by integrin
GO:0034241	positive regulation of macrophage fusion
GO:0034612	response to tumor necrosis factor
GO:0034616	response to laminar fluid shear stress
GO:0042117	monocyte activation
GO:0042542	response to hydrogen peroxide
GO:0050714	positive regulation of protein secretion
GO:0051044	positive regulation of membrane protein ectodomain proteolysis
GO:0051088	PMA-inducible membrane protein ectodomain proteolysis
GO:0051384	response to glucocorticoid
GO:0051549	positive regulation of keratinocyte migration
GO:0051592	response to calcium ion
GO:0071222	cellular response to lipopolysaccharide

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0031233	intrinsic to external side of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR001762 Blood coagulation inhibitor, Disintegrin
IPR002870 Peptidase M12B, propeptide
IPR006586 ADAM, cysteine-rich

PFAM

PF00008
PF01421
PF00200
PF01562
PF08516

PRINTS

PR00289

PIRSF

SMART

SM00181
SM00050
SM00608

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt