Version 5.4
Homo sapiens Protein: AKAP7
Summary
InnateDB Protein IDBP-475855.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AKAP7
Protein Name A kinase (PRKA) anchor protein 7
Synonyms AKAP15; AKAP18;
Species Homo sapiens
Ensembl Protein ENSP00000418208
InnateDB Gene IDBG-96473 (AKAP7)
Protein Structure
UniProt Annotation
Function Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium. {ECO:0000269PubMed:10613906, ECO:0000269PubMed:17244820, ECO:0000269PubMed:9545239}.
Subcellular Localization Isoform Alpha: Lateral cell membrane; Lipid- anchor. Note=Targeted predominantly to the lateral membrane.Isoform Beta: Apical cell membrane; Lipid- anchor. Note=Targeted predominantly to the apical membrane.
Disease Associations
Tissue Specificity Expressed in brain, heart, lung, pancreas and skeletal muscle. {ECO:0000269PubMed:9545239}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0051018 protein kinase A binding
Biological Process
GO:0001508 action potential
GO:0006811 ion transport
GO:0008104 protein localization
GO:0035556 intracellular signal transduction
GO:0060306 regulation of membrane repolarization
GO:0071320 cellular response to cAMP
GO:1901381 positive regulation of potassium ion transmembrane transport
GO:1902261 positive regulation of delayed rectifier potassium channel activity
Cellular Component
GO:0005886 plasma membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR019511 Protein kinase A anchor protein, RI-RII subunit-binding domain
PFAM PF10470
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43687
PhosphoSite PhosphoSite-O43687
TrEMBL
UniProt Splice Variant
Entrez Gene 9465
UniGene Hs.598696
RefSeq NP_619539
HUGO HGNC:377
OMIM 604693
CCDS CCDS5144
HPRD 16065
IMGT
EMBL AF047715 AF161075 AK290271 AL136110 AL137063 BC016927 BC073847 BC094732 CH471051
GenPept AAC39715 AAF26676 AAH16927 AAH73847 AAH94732 BAF82960 CAI19001 CAI19002 CAI21507 CAI21508 EAW48057

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca