InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADAMTS6

Summary

InnateDB Protein

IDBP-476034.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADAMTS6

Protein Name

ADAM metallopeptidase with thrombospondin type 1 motif, 6

Synonyms

ADAM-TS 6; ADAM-TS6; ADAMTS-6;

Species

Homo sapiens

Ensembl Protein

ENSP00000424377

InnateDB Gene

IDBG-23823 (ADAMTS6)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed at low levels in placenta and barely detectable in a number of other tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508

proteolysis

Cellular Component

GO:0005578

proteinaceous extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR002870 Peptidase M12B, propeptide

PFAM

PF01562

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UKP5

PhosphoSite

PhosphoSite-Q9UKP5

TrEMBL

UniProt Splice Variant

Entrez Gene

11174

UniGene

Hs.482291

RefSeq

HUGO

HGNC:222

OMIM

605008

CCDS

HPRD

05421

IMGT

EMBL

AB209685 AC008847 AC008868 AC025176 AC025186 AC099505 AF140674 AY692424 AY692425 AY692426 CR749356

GenPept

AAD56357 AAW47397 AAW47398 AAW47399 BAD92922 CAH18209