InnateDB Protein
|
IDBP-476044.4
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
CDC42SE2
|
Protein Name
|
CDC42 small effector 2
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000427421
|
InnateDB Gene
|
IDBG-40423 (CDC42SE2)
|
Protein Structure
|
|
Function |
Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages. {ECO:0000269PubMed:10816584, ECO:0000269PubMed:15840583}.
|
Subcellular Localization |
Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor. Cell projection, phagocytic cup. Note=Recruited to the activated TCR prior actin polymerization. Localizes at the phagocytic cup of macrophages.
|
Disease Associations |
|
Tissue Specificity |
Widely expressed. Expressed at higher level in T-lymphocytes. Highly expressed in CCRF-CEM T-lymphocytes, Jurkat T-lymphocytes, and Raji B-lymphocytes compared (at protein level). {ECO:0000269PubMed:15840583}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
|
Protein-Protein |
3
[view]
|
Protein-DNA |
0
|
Protein-RNA |
1
[view]
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000095
CRIB domain
|
PFAM |
PF00786
|
PRINTS |
|
PIRSF |
|
SMART |
SM00285
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9NRR3
|
PhosphoSite |
PhosphoSite-Q9NRR3
|
TrEMBL |
D6REL0
|
UniProt Splice Variant |
|
Entrez Gene |
56990
|
UniGene |
Hs.508829
|
RefSeq |
|
HUGO |
HGNC:18547
|
OMIM |
|
CCDS |
CCDS34224
|
HPRD |
16695
|
IMGT |
|
EMBL |
AC004777
AC005179
AC008497
AC009016
AC114275
AF189692
AK312406
BC096703
BC096738
BC098349
CH471062
|
GenPept |
AAF87598
AAH96703
AAH96738
AAH98349
BAG35319
EAW62373
|
|
|