InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GAPVD1

Summary

InnateDB Protein

IDBP-476175.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GAPVD1

Protein Name

GTPase activating protein and VPS9 domains 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000419063

InnateDB Gene

IDBG-85167 (GAPVD1)

Protein Structure

UniProt Annotation

Function

Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras. {ECO:0000269PubMed:16410077}.

Subcellular Localization

Membrane {ECO:0000269PubMed:16410077}; Peripheral membrane protein {ECO:0000269PubMed:16410077}. Endosome {ECO:0000269PubMed:16410077}. Note=Recruited to the plasma membrane by TRIP10/CIP4 in response to insulin.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005096	GTPase activator activity
GO:0032794	GTPase activating protein binding

Biological Process

GO:0006897	endocytosis
GO:0007165	signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0051223	regulation of protein transport

Cellular Component

GO:0005622	intracellular
GO:0005768	endosome
GO:0005829	cytosol
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001936 Ras GTPase-activating protein
IPR003123 Vacuolar sorting protein 9
IPR008936 Rho GTPase activation protein
IPR013995 Vacuolar sorting protein 9, subgroup

PFAM

PF00616
PF02204

PRINTS

PIRSF

SMART

SM00323
SM00167

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q14C86