InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RXRA

Summary

InnateDB Protein

IDBP-476267.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RXRA

Protein Name

retinoid X receptor, alpha

Synonyms

NR2B1;

Species

Homo sapiens

Ensembl Protein

ENSP00000419692

InnateDB Gene

IDBG-91747 (RXRA)

Protein Structure

UniProt Annotation

Function

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes. {ECO:0000269PubMed:10195690, ECO:0000269PubMed:11162439, ECO:0000269PubMed:11915042, ECO:0000269PubMed:20215566}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00407, ECO:0000269PubMed:11915042}.

Disease Associations

Tissue Specificity

Highly expressed in liver, also found in lung, kidney and heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 182 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	182 [view]
Protein-Protein	166 [view]
Protein-DNA	14 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0003708	retinoic acid receptor activity
GO:0003713	transcription coactivator activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004886	9-cis retinoic acid receptor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0031490	chromatin DNA binding
GO:0042809	vitamin D receptor binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0044323	retinoic acid-responsive element binding
GO:0046982	protein heterodimerization activity
GO:0070644	vitamin D response element binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0001890	placenta development
GO:0001893	maternal placenta development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006766	vitamin metabolic process
GO:0007507	heart development
GO:0007566	embryo implantation
GO:0008203	cholesterol metabolic process
GO:0010467	gene expression
GO:0019048	modulation by virus of host morphology or physiology
GO:0032526	response to retinoic acid
GO:0035357	peroxisome proliferator activated receptor signaling pathway
GO:0043010	camera-type eye development
GO:0043401	steroid hormone mediated signaling pathway
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048384	retinoic acid receptor signaling pathway
GO:0051289	protein homotetramerization
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0055012	ventricular cardiac muscle cell differentiation
GO:0060038	cardiac muscle cell proliferation
GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0060687	regulation of branching involved in prostate gland morphogenesis

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000003 Retinoid X receptor/HNF4
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR003068 Transcription factor COUP
IPR003078 Retinoic acid receptor
IPR008946 Nuclear hormone receptor, ligand-binding
IPR021780 Nuclear/hormone receptor activator site AF-1

PFAM

PF00104
PF00105
PF11825

PRINTS

PR00545
PR00047
PR00398
PR01282
PR01292

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt