InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC20A2

Summary

InnateDB Protein

IDBP-476438.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC20A2

Protein Name

solute carrier family 20 (phosphate transporter), member 2

Synonyms

GLVR-2; GLVR2; IBGC1; IBGC3; MLVAR; PIT-2; PIT2; RAM1;

Species

Homo sapiens

Ensembl Protein

ENSP00000429712

InnateDB Gene

IDBG-20276 (SLC20A2)

Protein Structure

UniProt Annotation

Function

Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. {ECO:0000269PubMed:11435563, ECO:0000269PubMed:12205090, ECO:0000269PubMed:15955065, ECO:0000269PubMed:16790504, ECO:0000269PubMed:8302848}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:9151850}; Multi-pass membrane protein {ECO:0000269PubMed:9151850}.

Disease Associations

Basal ganglia calcification, idiopathic, 1 (IBGC1) [MIM:213600]: A form of basal ganglia calcification, an autosomal dominant condition characterized by symmetric calcification in the basal ganglia and other brain regions. Affected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms, including parkinsonism, dystonia, tremor, ataxia, dementia, psychosis, seizures, and chronic headache. Serum levels of calcium, phosphate, alkaline phosphatase and parathyroid hormone are normal. The neuropathological hallmark of the disease is vascular and pericapillary calcification, mainly of calcium phosphate, in the affected brain areas. {ECO:0000269PubMed:22327515}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Ubiquitously expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001618	virus receptor activity
GO:0004872	receptor activity
GO:0005315	inorganic phosphate transmembrane transporter activity
GO:0005436	sodium:phosphate symporter activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006817	phosphate ion transport
GO:0009615	response to virus
GO:0016032	viral process
GO:0035435	phosphate ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0055085	transmembrane transport