Version 5.4
Homo sapiens Protein: SPINK13
Summary
InnateDB Protein IDBP-476657.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPINK13
Protein Name serine peptidase inhibitor, Kazal type 13 (putative)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000426279
InnateDB Gene IDBG-233048 (SPINK13)
Protein Structure
UniProt Annotation
Function May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250}. Note=Secreted into the lumen of the initial segment of the epididymis and binds to sperm. In the initial segment of epididymis, localizes on the dorsal surface of the acrosomal region of sperm, gradually becomes more restricted to the acrosomal region in spermatozoa during epididymal transit (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:1902225 negative regulation of acrosome reaction
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR002350 Kazal domain
PFAM PF00050
PF07648
PRINTS
PIRSF
SMART SM00280
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q1W4C9
PhosphoSite PhosphoSite-Q1W4C9
TrEMBL
UniProt Splice Variant
Entrez Gene 153218
UniGene Hs.483771
RefSeq
HUGO HGNC:27200
OMIM 615205
CCDS
HPRD
IMGT
EMBL BC128163 BC128164 CH471062 DQ438947
GenPept AAI28164 AAI28165 ABD96086 EAW61812

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca