InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RBBP7

Summary

InnateDB Protein

IDBP-47681.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RBBP7

Protein Name

retinoblastoma binding protein 7

Synonyms

RbAp46;

Species

Homo sapiens

Ensembl Protein

ENSP00000369424

InnateDB Gene

IDBG-47673 (RBBP7)

Protein Structure

UniProt Annotation

Function

Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. {ECO:0000269PubMed:10866654}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 155 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	155 [view]
Protein-Protein	155 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006260	DNA replication
GO:0006325	chromatin organization
GO:0006334	nucleosome assembly
GO:0006351	transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0008283	cell proliferation
GO:0030308	negative regulation of cell growth
GO:0034080	centromere-specific nucleosome assembly
GO:0045892	negative regulation of transcription, DNA-templated
GO:0070370	cellular heat acclimation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0016581	NuRD complex
GO:0035098	ESC/E(Z) complex

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
IPR022052 Histone-binding protein RBBP4, N-terminal

PFAM

PF00400
PF12265

PRINTS

PR00320

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt