InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DROSHA

Summary

InnateDB Protein

IDBP-476863.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DROSHA

Protein Name

drosha, ribonuclease type III

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000425979

InnateDB Gene

IDBG-14255 (DROSHA)

Protein Structure

UniProt Annotation

Function

Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA- ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double- strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. {ECO:0000269PubMed:10948199, ECO:0000269PubMed:14508493, ECO:0000269PubMed:15531877, ECO:0000269PubMed:15565168, ECO:0000269PubMed:15574589, ECO:0000269PubMed:15589161, ECO:0000269PubMed:16751099, ECO:0000269PubMed:16906129, ECO:0000269PubMed:17159994}.

Subcellular Localization

Nucleus. Nucleus, nucleolus. Note=A fraction is translocated to the nucleolus during the S phase of the cell cycle. Localized in GW bodies (GWBs), also known as P-bodies.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:10948199}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.

Experimentally validated
Total	55 [view]
Protein-Protein	54 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0003723	RNA binding
GO:0004521	endoribonuclease activity
GO:0004525	ribonuclease III activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006396	RNA processing
GO:0010467	gene expression
GO:0010468	regulation of gene expression
GO:0010586	miRNA metabolic process
GO:0016075	rRNA catabolic process
GO:0031053	primary miRNA processing
GO:0031054	pre-miRNA processing
GO:0042254	ribosome biogenesis
GO:0050829	defense response to Gram-negative bacterium
GO:0050830	defense response to Gram-positive bacterium
GO:0090501	RNA phosphodiester bond hydrolysis
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic