InnateDB Protein
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IDBP-476885.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FILIP1L
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Protein Name
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filamin A interacting protein 1-like
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Synonyms
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DOC-1; DOC1; GIP130; GIP90;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000417774
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InnateDB Gene
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IDBG-47184 (FILIP1L)
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Protein Structure
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Function |
Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor- associated vasculature. {ECO:0000269PubMed:18794120}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:18794120}. Membrane {ECO:0000269PubMed:18794120}. Nucleus {ECO:0000269PubMed:18794120}.
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Disease Associations |
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Tissue Specificity |
Expressed in endothelial cells, colon and colon cancers. In the colon, expressed in the vasculature and muscularis mucosa. In colon cancer, strongly expressed in tumor stroma and the vasculature (at protein level). Expressed in ovarian epithelial cells. Down-regulated in ovarian cancer. {ECO:0000269PubMed:18794120, ECO:0000269PubMed:8314147}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR009053
Prefoldin
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q4L180
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PhosphoSite |
PhosphoSite-Q4L180
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
11259
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UniGene |
Hs.727360
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RefSeq |
NP_001269722
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HUGO |
HGNC:24589
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OMIM |
612993
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CCDS |
CCDS74969
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HPRD |
16832
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IMGT |
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EMBL |
AC024938
AC069222
AC117419
AF329092
AF514867
AF514868
AF514869
AY642382
BC020941
BC027860
CH471052
EU531865
EU531866
U53445
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GenPept |
AAA98972
AAH20941
AAH27860
AAN16206
AAQ08177
AAQ08178
AAQ08179
AAV34207
ACB37436
ACB37437
EAW79833
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