InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GFM1

Summary

InnateDB Protein

IDBP-476890.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GFM1

Protein Name

G elongation factor, mitochondrial 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000419038

InnateDB Gene

IDBG-63156 (GFM1)

Protein Structure

UniProt Annotation

Function

Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A- site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. {ECO:0000255HAMAP-Rule:MF_03061, ECO:0000269PubMed:19716793}.

Subcellular Localization

Mitochondrion {ECO:0000255HAMAP- Rule:MF_03061}.

Disease Associations

Combined oxidative phosphorylation deficiency 1 (COXPD1) [MIM:609060]: A mitochondrial disease resulting in early rapidly progressive hepatoencephalopathy. {ECO:0000269PubMed:15537906, ECO:0000269PubMed:17160893}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003746	translation elongation factor activity
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006414	translational elongation
GO:0070125	mitochondrial translational elongation

Cellular Component

GO:0005622	intracellular
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR000640 Translation elongation factor EFG, V domain
IPR000795 Elongation factor, GTP-binding domain
IPR004161 Translation elongation factor EFTu/EF1A, domain 2
IPR004540 Translation elongation factor EFG/EF2
IPR005225 Small GTP-binding protein domain
IPR005517 Translation elongation factor EFG/EF2, domain IV
IPR009000 Translation protein, beta-barrel domain
IPR009022 Elongation factor G, III-V domain
IPR020568 Ribosomal protein S5 domain 2-type fold
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00679
PF00009
PF03144
PF03764
PF14492

PRINTS

PR00315

PIRSF

SMART

SM00838
SM00889

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt