Version 5.4
Homo sapiens Protein: SNCB
Summary
InnateDB Protein IDBP-476901.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNCB
Protein Name synuclein, beta
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000422223
InnateDB Gene IDBG-59051 (SNCB)
Protein Structure
UniProt Annotation
Function Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53- dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004859 phospholipase inhibitor activity
GO:0005509 calcium ion binding
Biological Process
GO:0043086 negative regulation of catalytic activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
Protein Structure and Domains
PDB ID
InterPro IPR001058 Synuclein
IPR002461 Beta-synuclein
PFAM PF01387
PRINTS PR01211
PR01213
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q16143
PhosphoSite PhosphoSite-Q16143
TrEMBL A0A024R7R3
UniProt Splice Variant
Entrez Gene 6620
UniGene
RefSeq XP_006714977
HUGO HGNC:11140
OMIM 602569
CCDS CCDS4406
HPRD 03980
IMGT
EMBL AF053134 AF053135 AF053136 BC002902 BT006627 CH471195 CR457027 S69965
GenPept AAB30860 AAC80286 AAH02902 AAP35273 CAG33308 EAW85063 EAW85064

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca