InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNIP1

Summary

InnateDB Protein

IDBP-477028.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNIP1

Protein Name

TNFAIP3 interacting protein 1

Synonyms

ABIN-1; NAF1; nip40-1; VAN;

Species

Homo sapiens

Ensembl Protein

ENSP00000430971

InnateDB Gene

IDBG-54098 (TNIP1)

Protein Structure

UniProt Annotation

Function

Inhibits NF-kappa-B activation and TNF-induced NF-kappa- B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti- inflammatory response of macrophages and positively regulates TLR- induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection. {ECO:0000269PubMed:12220502, ECO:0000269PubMed:16684768, ECO:0000269PubMed:17016622, ECO:0000269PubMed:17632516, ECO:0000269PubMed:20010814}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner.

Disease Associations

Tissue Specificity

Ubiquitous. Strongly expressed in peripheral blood lymphocytes, spleen and skeletal muscle, and is weakly expressed in the brain. In peripheral blood mononucleocytes, isoform 4 is mainly expressed and isoform 1 and isoform 7 are almost not expressed. Expression of isoform 1 and isoform 7 increases in leukemic cells. {ECO:0000269PubMed:17016622}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	63 [view]
Protein-Protein	57 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004843	ubiquitin-specific protease activity
GO:0005488	binding
GO:0005515	protein binding
GO:0051019	mitogen-activated protein kinase binding

Biological Process

GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0006412	translation
GO:0006952	defense response
GO:0006954	inflammatory response
GO:0007159	leukocyte cell-cell adhesion
GO:0009101	glycoprotein biosynthetic process
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050729	positive regulation of inflammatory response
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0085032	modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade