Version 5.4
Homo sapiens Protein: DHFR
Summary
InnateDB Protein IDBP-477083.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DHFR
Protein Name dihydrofolate reductase
Synonyms DHFRP1; DYR;
Species Homo sapiens
Ensembl Protein ENSP00000421334
InnateDB Gene IDBG-302986 (DHFR)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 12 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004146 dihydrofolate reductase activity
Biological Process
GO:0006545 glycine biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001796 Dihydrofolate reductase domain
IPR024072 Dihydrofolate reductase-like domain
PFAM PF00186
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL B4DDD2
UniProt Splice Variant
Entrez Gene 1719
UniGene Hs.83765
RefSeq NP_001277283
HUGO HGNC:2861
OMIM 126060
CCDS
HPRD 00519
IMGT
EMBL AC008434 AC010270 AK293146
GenPept BAG56693

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca