InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPIA

Summary

InnateDB Protein

IDBP-477219.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPIA

Protein Name

peptidylprolyl isomerase A (cyclophilin A)

Synonyms

CYPA; CYPH; HEL-S-69p;

Species

Homo sapiens

Ensembl Protein

ENSP00000419425

InnateDB Gene

IDBG-15159 (PPIA)

Protein Structure

UniProt Annotation

Function

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16527992}. Secreted {ECO:0000269PubMed:16527992}. Note=Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 83 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	83 [view]
Protein-Protein	79 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding
GO:0042277	peptide binding
GO:0044822	poly(A) RNA binding
GO:0046790	virion binding
GO:0051082	unfolded protein binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0002576	platelet degranulation
GO:0006278	RNA-dependent DNA replication
GO:0006457	protein folding
GO:0007596	blood coagulation
GO:0016032	viral process
GO:0019058	viral life cycle
GO:0019061	uncoating of virus
GO:0019068	virion assembly
GO:0019076	viral release from host cell
GO:0030168	platelet activation
GO:0030260	entry into host cell
GO:0034389	lipid particle organization
GO:0045069	regulation of viral genome replication
GO:0045070	positive regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0050714	positive regulation of protein secretion
GO:0050900	leukocyte migration
GO:0075713	establishment of integrated proviral latency

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005829	cytosol
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome