Homo sapiens Protein: TNS4
Summary
InnateDB Protein IDBP-47730.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNS4
Protein Name tensin 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000254051
InnateDB Gene IDBG-47726 (TNS4)
Protein Structure
UniProt Annotation
Function May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3. {ECO:0000250}.
Subcellular Localization Cell junction, focal adhesion {ECO:0000269PubMed:12154022}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:12154022}.
Disease Associations
Tissue Specificity Prostate and placenta. Down regulated in prostate cancer. {ECO:0000269PubMed:12154022}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0008104 protein localization
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
Protein Structure and Domains
PDB ID
InterPro IPR000980 SH2 domain
IPR006020 PTB/PI domain
IPR013625 Tensin phosphotyrosine-binding domain
PFAM PF00017
PF14633
PF00640
PF14719
PF08416
PRINTS PR00401
PIRSF
SMART SM00252
SM00462
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IZW8
PhosphoSite PhosphoSite-Q8IZW8
TrEMBL
UniProt Splice Variant
Entrez Gene 84951
UniGene Hs.438292
RefSeq NP_116254
HUGO HGNC:24352
OMIM 608385
CCDS CCDS11368
HPRD 12223
IMGT
EMBL AC018629 AF370421 AF417488 AK027856 BC018706
GenPept AAH18706 AAN32666 AAQ15257 BAB55413