InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STK3

Summary

InnateDB Protein

IDBP-477515.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STK3

Protein Name

serine/threonine kinase 3

Synonyms

KRS1; MST2;

Species

Homo sapiens

Ensembl Protein

ENSP00000429744

InnateDB Gene

IDBG-30072 (STK3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 119 experimentally validated interaction(s) in this database.

Experimentally validated
Total	119 [view]
Protein-Protein	118 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0043539	protein serine/threonine kinase activator activity
GO:0046983	protein dimerization activity

Biological Process

GO:0001841	neural tube formation
GO:0003157	endocardium development
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007417	central nervous system development
GO:0008285	negative regulation of cell proliferation
GO:0023014	signal transduction by phosphorylation
GO:0035329	hippo signaling
GO:0035556	intracellular signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0046330	positive regulation of JNK cascade
GO:0046621	negative regulation of organ growth
GO:0051897	positive regulation of protein kinase B signaling
GO:0060215	primitive hemopoiesis
GO:0060706	cell differentiation involved in embryonic placenta development
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0097284	hepatocyte apoptotic process
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011524 SARAH domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR024205 Mst1 SARAH domain

PFAM

PF00069
PF07714
PF11629

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt