Version 5.4
Homo sapiens Protein: IL12A
Summary
InnateDB Protein IDBP-477572.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL12A
Protein Name interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
Synonyms CLMF; IL-12A; NFSK; NKSF1; P35;
Species Homo sapiens
Ensembl Protein ENSP00000420184
InnateDB Gene IDBG-63368 (IL12A)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 11 [view]
Protein-DNA 18 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005143 interleukin-12 receptor binding
GO:0008083 growth factor activity
GO:0042163 interleukin-12 beta subunit binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006955 immune response
GO:0032946 positive regulation of mononuclear cell proliferation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0043514 interleukin-12 complex
Protein Structure and Domains
PDB ID
InterPro IPR004281 Interleukin-12 alpha
IPR009079 Four-helical cytokine-like, core
PFAM PF03039
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q7LDP2
UniProt Splice Variant
Entrez Gene 3592
UniGene Hs.673
RefSeq
HUGO HGNC:5969
OMIM 161560
CCDS
HPRD 01193
IMGT
EMBL AC010370 AF050083
GenPept AAC05211

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca