InnateDB Protein
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IDBP-477645.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PARP9
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Protein Name
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poly (ADP-ribose) polymerase family, member 9
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000419001
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InnateDB Gene
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IDBG-52594 (PARP9)
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Protein Structure
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Function |
In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes. {ECO:0000269PubMed:16809771, ECO:0000269PubMed:23230272}.
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Subcellular Localization |
Cytoplasm, cytosol. Nucleus. Note=Shuttles between the nucleus and the cytosol. Export to the cytosol depends on the interaction with DTX3L. Localizes at sites of DNA damage in a PARP1-dependent manner.
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Disease Associations |
Note=Overexpressed at significantly higher levels in fatal high-risk diffuse large B-cell lymphomas (DLB-CL) compared to cured low-risk tumors. Overexpression in B-cell lymphoma transfectants may promote malignant B-cell migration. May therefore be involved in promoting B-cell migration and dissemination of high-risk DLB-CL tumors.
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Tissue Specificity |
Expressed in lymphocyte-rich tissues, spleen, lymph nodes, peripheral blood lymphocytes and colonic mucosa. Also expressed in nonhematopoietic tissues such as heart and skeletal muscle. Isoform 2 is the predominant form. Most abundantly expressed in lymphomas with a brisk host inflammatory response. In diffuse large B-cell lymphomas tumors, expressed specifically by malignant B-cells. {ECO:0000269PubMed:11110709, ECO:0000269PubMed:16809771}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002589
Macro domain
IPR012317
Poly(ADP-ribose) polymerase, catalytic domain
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PFAM |
PF01661
PF00644
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PRINTS |
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PIRSF |
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SMART |
SM00506
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TIGRFAMs |
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Modification |
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SwissProt |
Q8IXQ6
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PhosphoSite |
PhosphoSite-Q8IXQ6
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TrEMBL |
Q658Y0
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UniProt Splice Variant |
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Entrez Gene |
83666
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UniGene |
Hs.634988
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RefSeq |
NP_001139576
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HUGO |
HGNC:24118
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OMIM |
612065
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CCDS |
CCDS54634
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HPRD |
10686
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IMGT |
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EMBL |
AC092908
AC096861
AF307338
AF307339
AK292959
AK313494
AL713679
AL832929
BC017463
BC039580
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GenPept |
AAH39580
AAK07558
AAK07559
BAF85648
BAG36276
CAD28483
CAH56290
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