Version 5.4
Homo sapiens Protein: ORAI2
Summary
InnateDB Protein IDBP-477653.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ORAI2
Protein Name ORAI calcium release-activated calcium modulator 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000417928
InnateDB Gene IDBG-33563 (ORAI2)
Protein Structure
UniProt Annotation
Function Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)- selective current by synergy with the Ca(2+) sensor, STIM1. {ECO:0000269PubMed:16807233, ECO:0000269PubMed:17452328}.
Subcellular Localization Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR012446 Calcium release-activated calcium channel protein
PFAM PF07856
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96SN7
PhosphoSite PhosphoSite-Q96SN7
TrEMBL C9JUY6
UniProt Splice Variant
Entrez Gene 80228
UniGene Hs.363308
RefSeq
HUGO HGNC:21667
OMIM 610929
CCDS CCDS5722
HPRD 09860
IMGT
EMBL AC093668 AF258552 AK027639 AK300574 BC069270 CH471197 CR457287
GenPept AAG23755 AAH69270 AAP22351 AAP22352 BAB55256 BAG62276 CAG33568 EAW50244 EAW50245 EAW50247 EAW50248

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca