Version 5.4
Homo sapiens Protein: SYNPO
Summary
InnateDB Protein IDBP-477665.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYNPO
Protein Name synaptopodin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000428378
InnateDB Gene IDBG-53794 (SYNPO)
Protein Structure
UniProt Annotation
Function Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Perikaryon {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Localized at the tight junction of cells. In brain, localized to the postsynaptic densities and in the perikarya. Associated with dendritic spines of a subset of synapses (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in cerebral cortex. {ECO:0000269PubMed:9314539}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0032233 positive regulation of actin filament bundle assembly
GO:0051492 regulation of stress fiber assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005923 tight junction
GO:0014069 postsynaptic density
GO:0015629 actin cytoskeleton
GO:0043197 dendritic spine
GO:0043204 perikaryon
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N3V7
PhosphoSite PhosphoSite-Q8N3V7
TrEMBL Q71HJ6
UniProt Splice Variant
Entrez Gene 11346
UniGene Hs.435228
RefSeq NP_001159681
HUGO HGNC:30672
OMIM 608155
CCDS CCDS54937
HPRD 12179
IMGT
EMBL AB028952 AF499136 AF499137 AF499138 AK127049 AK290178 AL831818 BC142683 BC146665 CH471062 Y11072
GenPept AAI42684 AAI46666 AAQ07402 AAQ07403 AAQ07404 BAA82981 BAF82867 CAA71955 CAD38532 EAW61715 EAW61716

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca