Version 5.4
Homo sapiens Protein: GLYCTK
Summary
InnateDB Protein IDBP-477676.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GLYCTK
Protein Name glycerate kinase
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000418951
InnateDB Gene IDBG-38597 (GLYCTK)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Isoform 1: Cytoplasm.Isoform 2: Cytoplasm. Mitochondrion.
Disease Associations D-glyceric aciduria (D-GA) [MIM:220120]: A rare metabolic disease characterized by chronic metabolic acidosis and a highly variable clinical phenotype. Clinical features range from an encephalopathic presentation with seizures, microcephaly, severe mental retardation and early death, to milder manifestations with only speech delay or even normal development. {ECO:0000269PubMed:20949620}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Widely expressed. {ECO:0000269PubMed:16753811}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008887 glycerate kinase activity
Biological Process
GO:0006468 protein phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IVS8
PhosphoSite PhosphoSite-Q8IVS8
TrEMBL
UniProt Splice Variant
Entrez Gene 132158
UniGene
RefSeq
HUGO HGNC:24247
OMIM 610516
CCDS
HPRD 13586
IMGT
EMBL AF448855 AK074215 AY134474 AY172690 AY189286 AY295075 BC021896 BC036862 BC042151 DQ352863
GenPept AAH21896 AAH36862 AAH42151 AAM95456 AAO17719 AAO86730 AAP41923 AAP51132 ABD22985 BAB85018

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca