InnateDB Protein
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IDBP-477805.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HMBOX1
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Protein Name
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homeobox containing 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000430238
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InnateDB Gene
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IDBG-15380 (HMBOX1)
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Protein Structure
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Function |
Transcription factor. Isoform 1 acts as a transcriptional repressor. Isoform 4 has very low activity as a transcriptional repressor. {ECO:0000269PubMed:16825764, ECO:0000269PubMed:19757162}.
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Subcellular Localization |
Nucleus. Cytoplasm. Note=Predominantly detected in cytoplasm.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Detected in pancreas, brain, spleen, placenta, prostate, thymus, liver, heart, bone marrow, skeletal muscle, stomach, uterus, testis, kidney, ovary, and colon. {ECO:0000269PubMed:16825764, ECO:0000269PubMed:19757162}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
13
[view]
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Protein-Protein |
13
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0045892
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negative regulation of transcription, DNA-templated
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GO:0045893
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positive regulation of transcription, DNA-templated
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Cellular Component |
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PDB ID |
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InterPro |
IPR006899
Hepatocyte nuclear factor 1, N-terminal
IPR010982
Lambda repressor-like, DNA-binding domain
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PFAM |
PF04814
PF13413
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6NT76
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PhosphoSite |
PhosphoSite-Q6NT76
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TrEMBL |
E5RHH9
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UniProt Splice Variant |
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Entrez Gene |
79618
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UniGene |
Hs.609468
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RefSeq |
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HUGO |
HGNC:26137
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OMIM |
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CCDS |
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HPRD |
07964
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IMGT |
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EMBL |
AC040975
AC091558
AC108449
AK025269
AK290683
AK295320
AY522342
BC009259
BC069242
CH471080
DQ153248
DQ269478
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GenPept |
AAH09259
AAH69242
AAS76643
AAZ81565
ABB82947
BAB15099
BAF83372
BAG58297
EAW63496
EAW63499
EAW63500
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