InnateDB Protein
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IDBP-477855.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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EIF5AL1
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Protein Name
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eukaryotic translation initiation factor 5A-like 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000430706
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InnateDB Gene
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IDBG-402229 (EIF5AL1)
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Protein Structure
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Function |
mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus, nuclear pore complex {ECO:0000250}. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001884
Translation elongation factor IF5A
IPR008991
Translation protein SH3-like domain
IPR012340
Nucleic acid-binding, OB-fold
IPR020189
Translation elongation factor, IF5A C-terminal
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PFAM |
PF01287
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PRINTS |
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PIRSF |
PIRSF003025
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6IS14
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PhosphoSite |
PhosphoSite-Q6IS14
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
143244
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UniGene |
Hs.741635
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RefSeq |
NP_001093162
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HUGO |
HGNC:17419
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OMIM |
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CCDS |
CCDS53546
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HPRD |
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IMGT |
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EMBL |
BC070048
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GenPept |
AAH70048
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