InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TXNRD3

Summary

InnateDB Protein

IDBP-477996.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TXNRD3

Protein Name

thioredoxin reductase 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000430031

InnateDB Gene

IDBG-54736 (TXNRD3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004791	thioredoxin-disulfide reductase activity
GO:0009055	electron carrier activity
GO:0015035	protein disulfide oxidoreductase activity
GO:0016491	oxidoreductase activity
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

Biological Process

GO:0045454	cell redox homeostasis
GO:0055114	oxidation-reduction process

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000815 Mercuric reductase
IPR001327 Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain
IPR002109 Glutaredoxin
IPR003953 FAD binding domain
IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
IPR006338 Thioredoxin/glutathione reductase selenoprotein
IPR011899 Glutaredoxin, eukaryotic/virial
IPR012336 Thioredoxin-like fold
IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase
IPR014025 Glutaredoxin subgroup
IPR016156 FAD/NAD-linked reductase, dimerisation domain
IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain

PFAM