InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SEC31A

Summary

InnateDB Protein

IDBP-478027.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEC31A

Protein Name

SEC31 homolog A (S. cerevisiae)

Synonyms

ABP125; ABP130; HSPC334; SEC31L1;

Species

Homo sapiens

Ensembl Protein

ENSP00000426886

InnateDB Gene

IDBG-27208 (SEC31A)

Protein Structure

UniProt Annotation

Function

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Associates with membranes in a GTP-dependent manner. {ECO:0000250}.

Disease Associations

Note=A chromosomal aberration involving SEC31A is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;4)(p23;q21) with ALK.

Tissue Specificity

Abundantly and ubiquitously expressed. {ECO:0000269PubMed:10574704, ECO:0000269PubMed:10788476}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	20 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0015031	protein transport
GO:0018279	protein N-linked glycosylation via asparagine
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0048208	COPII vesicle coating
GO:0051592	response to calcium ion
GO:0061024	membrane organization

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0012507	ER to Golgi transport vesicle membrane
GO:0030120	vesicle coat
GO:0030127	COPII vesicle coat
GO:0030134	ER to Golgi transport vesicle
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm