InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EPHA6

Summary

InnateDB Protein

IDBP-478038.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPHA6

Protein Name

EPH receptor A6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000423950

InnateDB Gene

IDBG-46387 (EPHA6)

Protein Structure

UniProt Annotation

Function

Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain and testis. {ECO:0000269PubMed:14726470}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0008150	biological_process
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0048013	ephrin receptor signaling pathway

Cellular Component

GO:0005575	cellular_component
GO:0005634	nucleus
GO:0005887	integral component of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt