InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD226

Summary

InnateDB Protein

IDBP-4781.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD226

Protein Name

CD226 molecule

Synonyms

DNAM-1; DNAM1; PTA1; TLiSA1;

Species

Homo sapiens

Ensembl Protein

ENSP00000280200

InnateDB Gene

IDBG-4779 (CD226)

Protein Structure

UniProt Annotation

Function

Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. {ECO:0000269PubMed:8673704}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed by peripheral blood T-lymphocytes. {ECO:0000269PubMed:8673704}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0001816	cytokine production
GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0002891	positive regulation of immunoglobulin mediated immune response
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0008037	cell recognition
GO:0033005	positive regulation of mast cell activation
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
GO:0050776	regulation of immune response
GO:0060369	positive regulation of Fc receptor mediated stimulatory signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0045121	membrane raft