InnateDB Protein
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IDBP-478195.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SPCS3
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Protein Name
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signal peptidase complex subunit 3 homolog (S. cerevisiae)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000427463
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InnateDB Gene
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IDBG-45423 (SPCS3)
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Protein Structure
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Function |
Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. {ECO:0000250}.
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Subcellular Localization |
Microsome membrane {ECO:0000250}; Single- pass type II membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
2
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007653
Signal peptidase 22kDa subunit
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PFAM |
PF04573
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PRINTS |
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PIRSF |
PIRSF016089
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P61009
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PhosphoSite |
PhosphoSite-P61009
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
60559
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UniGene |
Hs.613487
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RefSeq |
NP_068747
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HUGO |
HGNC:26212
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OMIM |
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CCDS |
CCDS54823
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HPRD |
08001
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IMGT |
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EMBL |
AK026302
AL136660
AY359044
BC047290
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GenPept |
AAH47290
AAQ89403
BAB15437
CAB66595
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