Version 5.4
Homo sapiens Protein: INSM2
Summary
InnateDB Protein IDBP-4784.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INSM2
Protein Name insulinoma-associated 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000306523
InnateDB Gene IDBG-4782 (INSM2)
Protein Structure
UniProt Annotation
Function May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in heart, liver, skeletal muscle, kidney and pancreas, and, to a lesser extent, in brain, lung and spleen. In the pancreas, expressed in islet cells, including insulin- and glucagon-producing alpha- and beta-cells, but not in acinar cells (at protein level). Detected in adrenal glands, particularly in the deeper layer of the cortex (at protein level). {ECO:0000269PubMed:21343251}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96T92
PhosphoSite PhosphoSite-Q96T92
TrEMBL
UniProt Splice Variant
Entrez Gene 84684
UniGene Hs.62813
RefSeq NP_115983
HUGO HGNC:17539
OMIM 614027
CCDS CCDS9657
HPRD 17152
IMGT
EMBL AB037912 AF260323 AK096639 AL160231 BC130377 BC130379 CH471078 JX403968
GenPept AAI30378 AAI30380 AAK49393 AFS33107 BAB69042 BAC04830 EAW65872

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca