InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LEF1

Summary

InnateDB Protein

IDBP-478545.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LEF1

Protein Name

lymphoid enhancer-binding factor 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000422840

InnateDB Gene

IDBG-33529 (LEF1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 68 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	68 [view]
Protein-Protein	59 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008301	DNA binding, bending
GO:0030284	estrogen receptor activity
GO:0030331	estrogen receptor binding
GO:0035326	enhancer binding
GO:0042393	histone binding
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0045295	gamma-catenin binding
GO:0070016	armadillo repeat domain binding
GO:0070742	C2H2 zinc finger domain binding

Biological Process

GO:0001569	patterning of blood vessels
GO:0001649	osteoblast differentiation
GO:0001755	neural crest cell migration
GO:0001756	somitogenesis
GO:0001837	epithelial to mesenchymal transition
GO:0002040	sprouting angiogenesis
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0008284	positive regulation of cell proliferation
GO:0010628	positive regulation of gene expression
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0016055	Wnt signaling pathway
GO:0016202	regulation of striated muscle tissue development
GO:0021542	dentate gyrus development
GO:0021854	hypothalamus development
GO:0021861	forebrain radial glial cell differentiation
GO:0021873	forebrain neuroblast division
GO:0021879	forebrain neuron differentiation
GO:0021943	formation of radial glial scaffolds
GO:0022408	negative regulation of cell-cell adhesion
GO:0022409	positive regulation of cell-cell adhesion
GO:0030223	neutrophil differentiation
GO:0030307	positive regulation of cell growth
GO:0030326	embryonic limb morphogenesis
GO:0030335	positive regulation of cell migration
GO:0030509	BMP signaling pathway
GO:0030854	positive regulation of granulocyte differentiation
GO:0030879	mammary gland development
GO:0032696	negative regulation of interleukin-13 production
GO:0032713	negative regulation of interleukin-4 production
GO:0032714	negative regulation of interleukin-5 production
GO:0042100	B cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043392	negative regulation of DNA binding
GO:0043401	steroid hormone mediated signaling pathway
GO:0043923	positive regulation by host of viral transcription
GO:0043966	histone H3 acetylation
GO:0043967	histone H4 acetylation
GO:0045063	T-helper 1 cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046632	alpha-beta T cell differentiation
GO:0048069	eye pigmentation
GO:0048341	paraxial mesoderm formation
GO:0048747	muscle fiber development
GO:0060021	palate development
GO:0060070	canonical Wnt signaling pathway
GO:0060325	face morphogenesis
GO:0060326	cell chemotaxis
GO:0060561	apoptotic process involved in morphogenesis
GO:0060710	chorio-allantoic fusion
GO:0061153	trachea gland development
GO:0071345	cellular response to cytokine stimulus
GO:0071353	cellular response to interleukin-4
GO:0071864	positive regulation of cell proliferation in bone marrow
GO:0071866	negative regulation of apoptotic process in bone marrow
GO:0071895	odontoblast differentiation
GO:0071899	negative regulation of estrogen receptor binding
GO:0090068	positive regulation of cell cycle process
GO:0090090	negative regulation of canonical Wnt signaling pathway