Version 5.4
Homo sapiens Protein: EIF4E1B
Summary
InnateDB Protein IDBP-478567.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF4E1B
Protein Name eukaryotic translation initiation factor 4E family member 1B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000427633
InnateDB Gene IDBG-59094 (EIF4E1B)
Protein Structure
UniProt Annotation
Function Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structure. {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
Biological Process
GO:0006413 translational initiation
GO:0006417 regulation of translation
Cellular Component
GO:0005737 cytoplasm
GO:0005845 mRNA cap binding complex
Protein Structure and Domains
PDB ID
InterPro IPR001040 Translation Initiation factor eIF- 4e
IPR023398 Translation Initiation factor eIF- 4e-like domain
PFAM PF01652
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A6NMX2
PhosphoSite PhosphoSite-A6NMX2
TrEMBL D6RHE2
UniProt Splice Variant
Entrez Gene 253314
UniGene Hs.448362
RefSeq XP_006714901
HUGO HGNC:33179
OMIM
CCDS CCDS47345
HPRD
IMGT
EMBL AC091934
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca