InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TIGIT

Summary

InnateDB Protein

IDBP-478590.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TIGIT

Protein Name

T cell immunoreceptor with Ig and ITIM domains

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000420552

InnateDB Gene

IDBG-50851 (TIGIT)

Protein Structure

UniProt Annotation

Function

Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. {ECO:0000269PubMed:19011627}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:19011627}; Single-pass type I membrane protein {ECO:0000269PubMed:19011627}.

Disease Associations

Tissue Specificity

Expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). {ECO:0000269PubMed:19011627}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding

Biological Process

GO:0032695	negative regulation of interleukin-12 production
GO:0032733	positive regulation of interleukin-10 production
GO:0050868	negative regulation of T cell activation