InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EPHA3

Summary

InnateDB Protein

IDBP-478678.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPHA3

Protein Name

EPH receptor A3

Synonyms

EK4; ETK; ETK1; HEK; HEK4; TYRO4;

Species

Homo sapiens

Ensembl Protein

ENSP00000419190

InnateDB Gene

IDBG-45928 (EPHA3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	23 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0048013	ephrin receptor signaling pathway

Cellular Component

GO:0005887

integral component of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001090 Ephrin receptor ligand binding domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003961 Fibronectin, type III
IPR008979 Galactose-binding domain-like
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011009 Protein kinase-like domain
IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
IPR016257 Ephrin receptor type-A /type-B
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF01404
PF07714
PF00041
PF01108
PF07699

PRINTS

PR00109

PIRSF

PIRSF000666

SMART

SM00615
SM00220
SM00060
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References