InnateDB Protein
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IDBP-47869.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ZFP42
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Protein Name
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zinc finger protein 42 homolog (mouse)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000317686
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InnateDB Gene
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IDBG-47867 (ZFP42)
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Protein Structure
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Function |
Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells (at protein level). Expressed in malignant kidney and several carcinoma cell lines (at protein level). Expressed in embryonic stem cells, kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells. Expressed in embryonal carcinomas, seminomas, malignant kidney and several carcinoma cell lines. {ECO:0000269PubMed:12110702, ECO:0000269PubMed:16344273, ECO:0000269PubMed:16424014, ECO:0000269PubMed:16865673}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007087
Zinc finger, C2H2
IPR015880
Zinc finger, C2H2-like
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PFAM |
PF00096
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PRINTS |
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PIRSF |
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SMART |
SM00355
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TIGRFAMs |
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Modification |
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SwissProt |
Q96MM3
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PhosphoSite |
PhosphoSite-Q96MM3
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
132625
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UniGene |
Hs.335787
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RefSeq |
NP_777560
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HUGO |
HGNC:30949
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OMIM |
614572
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CCDS |
CCDS3849
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HPRD |
15726
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IMGT |
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EMBL |
AC108073
AF450454
AK056719
AY429593
CH471056
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GenPept |
AAL47167
AAR07993
BAB71264
EAX04610
EAX04611
EAX04612
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