InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYD88

Summary

InnateDB Protein

IDBP-478730.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYD88

Protein Name

myeloid differentiation primary response gene (88)

Synonyms

MYD88D;

Species

Homo sapiens

Ensembl Protein

ENSP00000417848

InnateDB Gene

IDBG-25713 (MYD88)

Protein Structure

UniProt Annotation

Function

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine. {ECO:0000269PubMed:15361868, ECO:0000269PubMed:18292575, ECO:0000269PubMed:19506249, ECO:0000269PubMed:9013863}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15361868, ECO:0000269PubMed:15492225}.

Disease Associations

MYD88 deficiency (MYD88D) [MIM:612260]: Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age. {ECO:0000269PubMed:18669862}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:8957090}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 129 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.

Experimentally validated
Total	129 [view]
Protein-Protein	120 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	7 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	59 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005123	death receptor binding
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0070976	TIR domain binding

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0032481	positive regulation of type I interferon production
GO:0032740	positive regulation of interleukin-17 production
GO:0032747	positive regulation of interleukin-23 production
GO:0032755	positive regulation of interleukin-6 production
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0043066	negative regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050727	regulation of inflammatory response
GO:0050830	defense response to Gram-positive bacterium
GO:0070555	response to interleukin-1
GO:0070935	3'-UTR-mediated mRNA stabilization
GO:0071260	cellular response to mechanical stimulus