Version 5.4
Homo sapiens Protein: STAU2
Summary
InnateDB Protein IDBP-478779.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STAU2
Protein Name staufen, RNA binding protein, homolog 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000430611
InnateDB Gene IDBG-25658 (STAU2)
Protein Structure
UniProt Annotation
Function RNA-binding protein required for the microtubule- dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm. Nucleus. Nucleus, nucleolus. Endoplasmic reticulum. Note=Shuttles between the nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and requires the exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1- dependent and XPO1/CRM1-independent pathways. Found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in the actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic reticulum. Also recruited to stress granules (SGs) upon inhibition of translation or oxidative stress. These structures are thought to harbor housekeeping mRNAs when translation is aborted (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 17 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003725 double-stranded RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006810 transport
Cellular Component
GO:0005730 nucleolus
GO:0005783 endoplasmic reticulum
GO:0005874 microtubule
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NUL3
PhosphoSite PhosphoSite-Q9NUL3
TrEMBL E5RGQ5
UniProt Splice Variant
Entrez Gene 27067
UniGene Hs.735277
RefSeq
HUGO HGNC:11371
OMIM 605920
CCDS
HPRD 09328
IMGT
EMBL AC018620 AC027018 AC100784 AF459097 AF459098 AK001576 AK002152 AK023314 AK293496 AK294466 AK303104 BC008369 BC008370 CR627442 Y19062
GenPept AAH08369 AAH08370 AAN37926 AAN37927 BAA91766 BAA92111 BAB14522 BAH11522 BAH11778 BAH13900 CAB64341 CAH10527

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca