InnateDB Protein
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IDBP-478806.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SPTSSB
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Protein Name
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serine palmitoyltransferase, small subunit B
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000420115
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InnateDB Gene
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IDBG-63716 (SPTSSB)
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Protein Structure
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Function |
Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference, complexes with this subunit showing a clear preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. May play a role in signal transduction. {ECO:0000269PubMed:19416851}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expression is seen predominantly in the prostate epithelium with weaker expression in the fibroblasts and endothelial cells. {ECO:0000269PubMed:15777716}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR024512
Small subunit of serine palmitoyltransferase-like
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PFAM |
PF11779
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8NFR3
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PhosphoSite |
PhosphoSite-Q8NFR3
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
165679
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UniGene |
Hs.369104
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RefSeq |
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HUGO |
HGNC:24045
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OMIM |
610412
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CCDS |
CCDS33887
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HPRD |
16476
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IMGT |
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EMBL |
AF458592
AK312144
BC065208
BC071875
BC107756
CH471052
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GenPept |
AAH65208
AAH71875
AAI07757
AAM49720
BAG35080
EAW78616
EAW78617
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