InnateDB Protein
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IDBP-478860.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC12A8
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Protein Name
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solute carrier family 12 (potassium/chloride transporters), member 8
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000418783
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InnateDB Gene
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IDBG-281667 (SLC12A8)
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Protein Structure
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Function |
Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation. {ECO:0000269PubMed:11863360}.
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Subcellular Localization |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
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Disease Associations |
Note=SLC12A8 has been identified as a possible susceptibility gene for psoriasis mapped to chromosome 3q21 (PSORS5).
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Tissue Specificity |
Ubiquitous with very low level in normal skin. {ECO:0000269PubMed:11863360}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004841
Amino acid permease/ SLC12A domain
IPR011527
ABC transporter type 1, transmembrane domain
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PFAM |
PF00324
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
A0AV02
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PhosphoSite |
PhosphoSite-A0AV02
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TrEMBL |
C9IZN2
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UniProt Splice Variant |
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Entrez Gene |
84561
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UniGene |
Hs.658514
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RefSeq |
NP_078904
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HUGO |
HGNC:15595
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OMIM |
611316
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CCDS |
CCDS43143
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HPRD |
11563
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IMGT |
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EMBL |
AC055752
AC108688
AC117488
AF345197
AF389851
AF390442
AK026841
BC020506
BC063528
BC126158
BC126160
BX538023
CR457363
CR749632
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GenPept |
AAH20506
AAH63528
AAI26159
AAI26161
AAK94307
AAM73657
AAO49174
BAB15571
CAD97969
CAG33644
CAH18426
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