InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PIK3R1

Summary

InnateDB Protein

IDBP-478883.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIK3R1

Protein Name

phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

Synonyms

AGM7; GRB1; IMD36; p85; p85-ALPHA;

Species

Homo sapiens

Ensembl Protein

ENSP00000430098

InnateDB Gene

IDBG-25037 (PIK3R1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 274 experimentally validated interaction(s) in this database.
They are also associated with 57 interaction(s) predicted by orthology.

Experimentally validated
Total	274 [view]
Protein-Protein	273 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	57 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005158	insulin receptor binding
GO:0005159	insulin-like growth factor receptor binding
GO:0005168	neurotrophin TRKA receptor binding
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019903	protein phosphatase binding
GO:0035014	phosphatidylinositol 3-kinase regulator activity
GO:0043125	ErbB-3 class receptor binding
GO:0043548	phosphatidylinositol 3-kinase binding
GO:0043559	insulin binding
GO:0043560	insulin receptor substrate binding

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007596	blood coagulation
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0014065	phosphatidylinositol 3-kinase signaling
GO:0016032	viral process
GO:0030168	platelet activation
GO:0031295	T cell costimulation
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043551	regulation of phosphatidylinositol 3-kinase activity
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0046326	positive regulation of glucose import
GO:0046854	phosphatidylinositol phosphorylation
GO:0048009	insulin-like growth factor receptor signaling pathway
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0050852	T cell receptor signaling pathway
GO:0050900	leukocyte migration
GO:0060396	growth hormone receptor signaling pathway
GO:0090004	positive regulation of establishment of protein localization to plasma membrane

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005942	phosphatidylinositol 3-kinase complex
GO:0005943	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex
GO:0016020	membrane